Twitterific is one of the well known application in the app store for Twitter on iPhone. I installed it and used it for a while until I recently found out about Hahlo, a web based mobile client for Twitter. Awesome!! When using both you do not see which one is web based!
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From Wapreview: Mobile Browser Based Applications
Two requirements need to be met before browser based technologies are capable being a general replacement for applications:
1. They need to be functional offline. The ability to edit a document can’t depend on the availability of a network signal.
2. There needs to be access to core phone features like the phone book, calendar, camera and location.